Performance of Prenatal Screening Tests
Screening Modality | Chromosome Difference | Sensitivity (Detection Rate) % (95% CI) | False Positive Rate % (95% CI) |
---|---|---|---|
eFTS |
Trisomy 21 |
89.02 (86.68, 91.08) |
6.34 (6.25, 6.43) |
STS | Trisomy 21 |
86.79 (74.66, 94.52)θ |
7.88 (7.56, 8.22)θ |
eFTS | Trisomy 18 |
84.98 (79.73, 89.31) |
0.26 (0.24, 0.28) |
STS | Trisomy 18 |
S (38.38, 88.18)Ψ |
0.58 (0.49, 0.68) |
Chromosome Difference | Sensitivity (Detection Rate) % (95% CI) | False Positive Rate % (95% CI) | Positive Predictive Value % (95% CI) | Negative Predictive Value % (95% CI) |
---|---|---|---|---|
Trisomy 21 |
99.49 (98.82, 99.84) |
0.07 (0.05, 0.09) |
95.71 (94.28, 96.86) |
99.99 (99.98, 100.00) |
Trisomy 18 |
95.96 (92.48, 98.14) |
0.03 (0.02, 0.04) |
92.64 (88.48, 95.65) |
99.99 (99.97, 99.99) |
Trisomy 13 |
92.11 (83.60, 97.05) |
0.04 (0.02, 0.06) |
71.43 (61.42, 80.10) |
99.99 (99.98, 100.00) |
Chromosome Difference | Sensitivity (Detection Rate) % (95% CI) | False Positive Rate % (95% CI) | Positive Predictive Value % (95% CI) | Negative Predictive Value % (95% CI) |
---|---|---|---|---|
Trisomy 21 |
99.55 (98.85, 99.88) |
0.10 (0.07, 0.13) |
95.76 (94.24, 96.97) |
99.99 (99.97, 100.00) |
Trisomy 18 |
95.54 (91.71, 97.94) |
0.03 (0.02, 0.05) |
93.69 (89.45, 96.60) |
99.98 (99.96, 99.99) |
Trisomy 13 |
92.42 (83.20, 97.49) |
0.05 (0.03, 0.08) |
73.49 (62.66, 82.58) |
99.99 (99.97, 100.00) |
Performance of Prenatal Screening System: The Basics

The aim of this analysis was to measure the performance of Ontario's prenatal screening system for the detection of trisomy 21 and trisomy 18.

Evaluating real-world prenatal screening system performance is important for making improvements to the system, and facilitating decision making for pregnant individuals.

Singleton pregnancies with an estimated due date between September 1, 2016 and March 31, 2021 who underwent publicly funded and/or private-pay prenatal screening.

The analysis examined routinely collected data from BORN Ontario, the province's perinatal registry. BORN Ontario collects critical health data about every pregnancy, birth and newborn in Ontario.
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