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  • What We Screen For In Ontario
    • Trisomy 21 (Down Syndrome)
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    • Enhanced First Trimester Screening Results
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    • enhanced First Trimester Screening (eFTS) Guide
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HomeResults and Next StepsEnhanced First Trimester Screening ResultsScreen Negative Results
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Screen Negative Results

Prenatal genetic screening tests, like enhanced First Trimester Screening or Second Trimester Screening, can give you results that are either "screen negative" or "screen positive". If your test result is "screen negative", you might have questions about what this means and what the next steps are.

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| What the result means

A "screen negative" result means there that there is a lower chance for the pregnancy to have  trisomy 21 (Down syndrome) or trisomy 18 (Edwards syndrome). A lower chance does not mean "no chance". 

If you do not see a result for trisomy 18 on the report, it means the result is "screen negative" for this chromosome difference.  Information about trisomy 18 is not on the report unless the result is flagged as "screen positive".

Understanding the cut-off

The screening test has a cut-off of 1 in 350 for trisomy 21. If you got a "screen negative" result, it is because the chance for the baby to have trisomy 21 was calculated to be less than 1 in 350.  

Understanding your chance

A number on the report gives your specific chance that the baby has trisomy 21.

For example: 

You got a "screen negative" result for trisomy 21, and the number on your report is 1 in 500.

This means out of 500 people who get this result, 1 will have a pregnancy with trisomy 21, and the other 499 people will not (see figure).  You can also think of it as a 0.2% chance for the baby to have trisomy 21, and a 99.8% chance for the baby to not have trisomy 21. 

provider report

| Next steps

You will get routine pregnancy care if there are no other concerns with your pregnancy. 

You can have a 18-22 week (detailed anatomy) ultrasound to check how the baby is growing and developing. This ultrasound is offered to all pregnant people, no matter what their prenatal genetic screening results are.

Many people do not do any more testing after they get a "screen negative" result. However, some people will think about having another screening test called Non-Invasive Prenatal Testing (NIPT). NIPT is only OHIP-funded in certain situations. Some might choose to pay for this test out-of-pocket.

 

  • Results and Next Steps
    • Enhanced First Trimester Screening Results
      Toggle Section Enhanced First Trimester Screening Results Menu
      • Screen Negative Results
      • Screen Positive Results
    • Second Trimester Screening Results
      Toggle Section Second Trimester Screening Results Menu
      • Screen Negative Results
      • Screen Positive Results
    • Screening for Vanishing Twins Results
      Toggle Section Screening for Vanishing Twins Results Menu
      • Screen Negative Results
      • Screen Positive Results
    • Non-invasive Prenatal Testing (NIPT) Results
      Toggle Section Non-invasive Prenatal Testing (NIPT) Results Menu
      • Low risk NIPT Results
      • High risk NIPT Results
      • No NIPT Result
    • 11-14 Week (Nuchal Translucency) Ultrasound Results
    • 18-22 Week Ultrasound Results
    • Diagnostic Testing
      Toggle Section Diagnostic Testing Menu
      • Chorionic villus sampling
      • Amniocentesis

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Prenatal Screening Ontario 
CHEO Research Institute 
Centre for Practice-Changing Research Building 
401 Smyth Road 
Ottawa, ON K1H 8L1

Phone: 613-737-2281

Toll-Free: 1-833-351-6490

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