The fetal nuchal translucency (NT) is a collection of fluid that is present at the back of the fetal neck in the first trimester of pregnancy. An increased NT measurement can be a normal variant, but is associated with a higher chance for chromosome differences, cardiac defects and other conditions.

A sonographer or physician measures the thickness of the fetal NT when the fetal crown rump length (CRL) is between 45mm and 84mm (approximately 11 ̶ 14 weeks gestation). If the pregnant individual is having enhanced First Trimester Screening (eFTS) or screening for vanishing twins/co-twin demise, this NT measurement is submitted to one of the three Ontario MMS laboratories along with a blood sample. The laboratories use this measurement along with clinical information and biochemical serum markers to calculate the individual chance for a pregnancy to have trisomy 21 (Down Syndrome) or trisomy 18. The NT measurement is the most heavily weighted factor in this equation.
Visit the Fetal Medicine Foundation (FMF UK) website for more information about the fetal NT, the relationship between the NT measurement and prenatal screening, and the diagnostic requirements of NT ultrasound.