Enhanced first trimester screening for trisomy 21 with contingent cell-free fetal DNA: a comparative performance and cost analysis

This study compared four prenatal screening strategies to integrate cell-free DNA screening into a publicly funded prenatal screening algorithm. The results suggest that using enhanced first trimester screening (eFTS) with contingent cfDNA screening following a positive eFTS result is a cost-effective system that doesn't compromise screening performance.

JOGC 2017;39(9):742-749; doi: 10.1016/j.jogc.2017.01.025