Performance of a universal prenatal screening program incorporating cell-free fetal DNA analysis in Ontario

This study described the population-based performance of Ontario's prenatal screening program, which incorporates publicly funded cfDNA screening for specific indications, and the effect of cfDNA testing on the screening and diagnostic choices made by pregnant people. This publicly funded screening program showed robust performance, a substantial reduction in prenatal diagnostic testing and that pregnant people exercise autonomy in their choices about prenatal screening and diagnosis.

CMAJ 2021;193(30):E1156-E1163; doi: 10.1503/cmaj.202456.